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bioRxiv · 10.1101/2024.02.09.579735

Discovery of Phenyl-β-D-glucuronide Medical Function for in Vivo Producing Handheld Gas Sensor Detectable Phenol-like Breath Marker: The Future of Induced Volatolomics in Cancer Risk Pre-warning

Xue, C. L.·Yan, Y. F.·Ni, H. Y.·Yi, H. C.·Xu, Y. L.·Xiang, S. Y.·Wu, Y. J.·Jin, H.·Cui, D. x.
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Abstract

Induced volatolomics provides a promising approach for cancer risk pre-warning. Nevertheless, continues to be questioned bio-compatibility of the synthetic exogenous agents and sophisticated instrument solely detectable isotopes labeled volatile compounds restrained induced volatolomics in clinic application. Here, we report phenyl-{beta}-D-glucuronide as a potential exogenous agent of induced volatolomics. As a nature product, phenyl-{beta}-D-glucuronide demonstrates satisfactory bio-compatibility in pilot study and metabolizes into volatile phenol under the action of tumor micro-environment highly accumulated {beta}-glucuronidase. For conveniently recording breath signal, handheld breath-analyzer based on electrochemical phenol sensor is developed. After administrating healthy or tumor bearing mice with phenyl-{beta}-D-glucuronide, breath signal given by breath-analyzer is verified to be capable of not only predicting various tumor risk with specificity/sensitivity/accuracy above 94.3% in 10 min, but also speculating tumor stage.

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Xue, C. L., Yan, Y. F., Ni, H. Y., Yi, H. C., Xu, Y. L., Xiang, S. Y., Wu, Y. J., Jin, H., Cui, D. x.. 2024-02-12. Discovery of Phenyl-β-D-glucuronide Medical Function for in Vivo Producing Handheld Gas Sensor Detectable Phenol-like Breath Marker: The Future of Induced Volatolomics in Cancer Risk Pre-warning. https://doi.org/10.1101/2024.02.09.579735

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