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bioRxiv · 10.1101/2024.02.04.578837

Wavelet Phase Coherence of Ictal Scalp EEG-Extracted Muscle Activity (SMA) as a Biomarker for Sudden Unexpected Death in Epilepsy (SUDEP)

Gravitis, A. C.·Sivendiran, K.·Tufa, U.·Zukotynski, K.·Chinvarun, Y.·Devinsky, O.·Wennberg, R.·Carlen, P. L.·Bardakjian, B. L.
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Abstract

ObjectiveApproximately 50 million people worldwide have epilepsy and 8-17% of the deaths in patients with epilepsy are attributed to sudden unexpected death in epilepsy (SUDEP). The goal of the present work was to establish a biomarker for SUDEP so that preventive treatment can be instituted. ApproachSeizure activity in patients with SUDEP and non-SUDEP was analyzed, specifically, the scalp EEG extracted muscle activity (SMA) and the average wavelet phase coherence (WPC) during seizures was computed for two frequency ranges (1-12 Hz, 13-30 Hz) to identify differences between the two groups. Main resultsIctal SMA in SUDEP patients showed a statistically higher average WPC value when compared to non-SUDEP patients for both frequency ranges. Area under curve for a cross-validated logistic classifier was 81%. SignificanceAverage WPC of ictal SMA is a candidate biomarker for early detection of SUDEP.

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Gravitis, A. C., Sivendiran, K., Tufa, U., Zukotynski, K., Chinvarun, Y., Devinsky, O., Wennberg, R., Carlen, P. L., Bardakjian, B. L.. 2024-02-06. Wavelet Phase Coherence of Ictal Scalp EEG-Extracted Muscle Activity (SMA) as a Biomarker for Sudden Unexpected Death in Epilepsy (SUDEP). https://doi.org/10.1101/2024.02.04.578837

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