Cell lipotypes localization in brain by mass spectrometry imaging

Martinez-Gardeazabal, J.; Moreno-Rodriguez, M.; Llorente-Ovejero, A.; Gonzalez de San Roman, E.; Lombardero, L.; Bengoetxea de Tena, I.; Sustacha, J.; Matute, C.; Manuel, I.; Bonifazi, P.; Rodriguez-Puertas, R.

doi:10.1101/2024.02.02.578599

bioRxiv · 10.1101/2024.02.02.578599

Cell lipotypes localization in brain by mass spectrometry imaging

Martinez-Gardeazabal, J.·Moreno-Rodriguez, M.·Llorente-Ovejero, A.·Gonzalez de San Roman, E.·Lombardero, L.·Bengoetxea de Tena, I.·Sustacha, J.·Matute, C.·Manuel, I.·Bonifazi, P.·Rodriguez-Puertas, R.

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Abstract

The study investigates brain lipid super-specialisation by defining characteristic spectral lipotypic profiles for the five primary cerebral cell-types. Utilizing a computational approach, the research visualizes the anatomical distribution of these profiles with high spatial resolution in brain tissues. This method unveils cellular stereotypic lipidic signatures within the CNS, providing a new framework for exploring the physiological roles of lipids in diverse cell-types present in brain or in any other tissue.

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Martinez-Gardeazabal, J., Moreno-Rodriguez, M., Llorente-Ovejero, A., Gonzalez de San Roman, E., Lombardero, L., Bengoetxea de Tena, I., Sustacha, J., Matute, C., Manuel, I., Bonifazi, P., Rodriguez-Puertas, R.. 2024-02-04. Cell lipotypes localization in brain by mass spectrometry imaging. https://doi.org/10.1101/2024.02.02.578599

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