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bioRxiv · 10.1101/2024.01.29.577841

AC-BioSD : A biomolecular signal differentiator module with enhanced performance

Alexis, E.·Avalos, J. L.·Cardelli, L.·Papachristodoulou, A.
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Abstract

Temporal gradient estimation is a pervasive phenomenon in natural biological systems and holds great promise for synthetic counterparts with broad-reaching applications. Here, we advance the concept of BioSD (Biomolecular Signal Differentiators) by introducing a novel biomolecular topology, termed Autocatalytic-BioSD or AC-BioSD. Its structure allows for insensitivity to input signal changes and high precision in terms of signal differentiation, even when operating far from nominal conditions. Concurrently, disruptive high-frequency signal components are effectively attenuated. In addition, the usefulness of our topology in biological regulation is highlighted via a PID (Proportional-Integral-Derivative) bio-control scheme with set point weighting and filtered derivative action in both the deterministic and stochastic domains.

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Alexis, E., Avalos, J. L., Cardelli, L., Papachristodoulou, A.. 2024-01-30. AC-BioSD : A biomolecular signal differentiator module with enhanced performance. https://doi.org/10.1101/2024.01.29.577841

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