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bioRxiv · 10.1101/2024.01.28.577644

Formation of long-term memory without short-term memory by CaMKII inhibition

Shin, M. E.·Parra-Bueno, P.·Yasuda, R.
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Abstract

Most of the current models of long-term memory consolidation require prior establishment of short-term memory. Here, we show that optogenetic or genetic inhibition of CaMKII, a kinase important for synaptic plasticity, in an inhibitory avoidance task impairs short-term memory at 1 h but not long-term memory at 1 d. Similarly, cortico-amygdala synaptic potentiation was more sensitive to CaMKII inhibition at 1 h but not at 1 d. These results strongly suggest that long-term memory does not require the prior formation of short-term memory and that CaMKII-dependent synaptic plasticity specifically regulates short-term memory, but not long-term memory, for avoidance memory.

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Shin, M. E., Parra-Bueno, P., Yasuda, R.. 2024-01-29. Formation of long-term memory without short-term memory by CaMKII inhibition. https://doi.org/10.1101/2024.01.28.577644

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