Planar, Spiral, and Concentric Traveling Waves Distinguish Cognitive States in Human Memory

Abstract

A fundamental challenge in neuroscience is explaining how widespread brain regions flexibly interact to support behaviors. We hypothesize that traveling waves of oscillations are a key mechanism of neural coordination, such that they propagate across the cortex in distinctive patterns that control how different regions interact. To test this hypothesis, we used direct brain recordings from humans performing multiple memory experiments and an analytical framework that flexibly measures the propagation patterns of traveling waves. We found that traveling waves propagated along the cortex in not only plane waves, but also spirals, sources and sinks, and more complex patterns. The propagation patterns of traveling waves correlated with novel aspects of behavior, with specific wave shapes reflecting particular cognitive processes and even individual remembered items. Our findings suggest that large-scale cortical patterns of traveling waves reveal the spatial organization of cognitive processes in the brain and may be relevant for neural decoding.