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bioRxiv · 10.1101/2024.01.26.577059

Cell aspect ratio is a mechanical winning strategy in microbial competition

Abstract

Bacterial competition shapes community architecture, yet a universally conserved determinant remains elusive. We show that cell aspect ratio -a simple morphological feature- confers a competitive advantage. Using growth-based range expansion experiments, we show that longer bacteria conquer the expanding front, even when initially in minority. Using an agent-based model of dividing bacteria, to isolate the effect of aspect ratio, we reveal that the takeover mechanism is collective alignment: groups of locally aligned bacteria form "nematic arms" bridging the central region of the colony to the expanding front. Once at the front, bacteria align parallel to it and block shorter bacteria from access to nutrients and space. We confirm this observation with single-cell experiments and further generalise our findings by introducing a generic continuum model of alignment-dominated competition, explaining both experimental and cell-based model observations. Moreover, we extend our predictions to spherical range expansions and confirm the competitive advantage, even though the effect is less pronounced than in surface-attached colonies. Our results uncover a simple, yet hitherto overlooked, mechanical mechanism determining the outcome of bacterial competition, which is potentially ubiquitous among various bacteria. Current advances in genetic engineering enable aspect ratio tuning as a mechanism with broad implications for biofilm control.

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van den Berg, N., Thijssen, K., Nguyen, T. T., Sarlet, A., Cordero, M., Vazquez, A. G., Mitarai, N., Doostmohammadi, A., Jauffred, L.. 2024-01-27. Cell aspect ratio is a mechanical winning strategy in microbial competition. https://doi.org/10.1101/2024.01.26.577059

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