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bioRxiv · 10.1101/2024.01.15.574570

Nitrous oxide respiration in acidophilic methanotrophs

Abstract

Methanotrophic bacteria mitigate methane (CH4) emissions from natural environments. Although aerobic methanotrophs are considered strict aerobes, they are often highly abundant in extremely hypoxic and even anoxic environments. Despite the presence of denitrification genes, it remains to be verified whether denitrification contributes to their growth. Here, we revealed that two acidophilic methanotrophs encoding N2O reductase (clade I and type II nosZ, respectively): Methylocella tundrae T4 and Methylacidiphilum caldifontis IT6, respired N2O and grew anaerobically on diverse non-methane substrates, including methanol, C-C substrates, and hydrogen. However, NO3 - and NO2 - could be reduced during methanol oxidation in Methylocella tundrae T4 and Methylocella silvestris BL2 without significantly increasing cell biomass. The lack of growth on methanol + NO3- or NO2- was likely due to the production of toxic reactive nitrogen species and C1 metabolites. However, the oxidation of pyruvate, a C3 electron donor, combined with NO3- or NO2- reduction resulted in anaerobic growth of Methylocella tundrae T4 and Methylocella silvestris BL2. In the extreme acidophile, Methylacidiphilum caldifontis IT6, N2O respiration supported cell growth at an extremely acidic pH of 2.0. In Methylocella tundrae T4, simultaneous consumption of N2O and CH4 was observed in suboxic conditions, both in microrespirometry and growth experiments, indicating the robustness of its N2O reductase activity in the presence of O2. Furthermore, CH4 oxidation per O2 reduced in O2-limiting conditions increased when N2O was added, indicating that cells of T4 can direct more O2 towards methane monooxygenase when respiring N2O as a terminal electron acceptor. Upregulation of nosZ and distinct repertories of methanol dehydrogenase-encoding genes (XoxF- and MxaFI-type) in Methylocella tundrae T4 cells grown anaerobically on methanol with N2O as the sole electron acceptor indicated adaptation mechanisms to anoxia. Our findings demonstrate that some methanotrophs can respire N2O independently or in tandem with O2, significantly expanding their potential ecological niche and paving the way for enhanced growth and survival in dynamic environments. This metabolic capability has application potential for simultaneously mitigating the emissions of the key greenhouse gases, CO2, CH4, and N2O, from natural and engineered environments.

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BibTeXRIS

Awala, S. I., Gwak, J.-H., Kim, Y., Jung, M.-Y., Dunfield, P. F., Wagner, M., Rhee, S.-K.. 2024-01-16. Nitrous oxide respiration in acidophilic methanotrophs. https://doi.org/10.1101/2024.01.15.574570

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