A neural network for religious fundamentalism derived from patients with brain lesions

Ferguson, M. A.; Asp, E. W.; Kletenik, I.; Tranel, D.; Boes, A.; Nelson, J. M.; Schaper, F. L.; Siddiqi, S. H.; Anderson, J. S.; Nielsen, J. A.; Bateman, J. R.; Grafman, J.; Fox, M. D.

doi:10.1101/2023.12.22.572527

bioRxiv · 10.1101/2023.12.22.572527

A neural network for religious fundamentalism derived from patients with brain lesions

Ferguson, M. A.·Asp, E. W.·Kletenik, I.·Tranel, D.·Boes, A.·Nelson, J. M.·Schaper, F. L.·Siddiqi, S. H.·Anderson, J. S.·Nielsen, J. A.·Bateman, J. R.·Grafman, J.·Fox, M. D.

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Abstract

Religious fundamentalism, characterized by rigid adherence to a set of beliefs putatively revealing inerrant truths, is ubiquitous across cultures and has a global impact on society. Understanding the psychological and neurobiological processes producing religious fundamentalism may inform a variety of scientific, sociological, and cultural questions. Research indicates that brain damage can alter religious fundamentalism. However, the precise brain regions involved with these changes remain unknown. Here, we analyzed brain lesions associated with varying levels of religious fundamentalism in two large datasets from independent laboratories. Lesions associated with greater fundamentalism were connected to a specific brain network with nodes in the right orbitofrontal, dorsolateral prefrontal, and inferior parietal lobes. This fundamentalism network was strongly right hemisphere lateralized and highly reproducible across the independent datasets (r = 0.82) with cross-validations between datasets. To explore the relationship of this network to lesions previously studied by our group, we tested for similarities to twenty-one lesion-induced conditions. Lesions associated with confabulation and criminal behavior showed a similar connectivity pattern as lesions associated with greater fundamentalism. Moreover, lesions associated with poststroke pain showed a similar connectivity pattern as lesions associated with lower fundamentalism. These findings are consistent with hemispheric specializations in reasoning and lend insight into previously observed epidemiological associations with fundamentalism, such as cognitive rigidity and outgroup hostility.

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Ferguson, M. A., Asp, E. W., Kletenik, I., Tranel, D., Boes, A., Nelson, J. M., Schaper, F. L., Siddiqi, S. H., Anderson, J. S., Nielsen, J. A., Bateman, J. R., Grafman, J., Fox, M. D.. 2023-12-29. A neural network for religious fundamentalism derived from patients with brain lesions. https://doi.org/10.1101/2023.12.22.572527

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