Experimental Validation of an Organ-on-Chip for Mechanical Stimulation of Cell Cultures

Testa, M.; Tornabene, S.; Di Leonardo, S.; Burriesci, G.; La Carrubba, V.; Lopresti, F.

doi:10.1101/2023.12.15.571835

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bioRxiv · 10.1101/2023.12.15.571835

Experimental Validation of an Organ-on-Chip for Mechanical Stimulation of Cell Cultures

Testa, M.·Tornabene, S.·Di Leonardo, S.·Burriesci, G.·La Carrubba, V.·Lopresti, F.

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Abstract

This paper focuses on the design, fabrication, and characterization of a platform aiming to dynamically culture cells under mechanical stimulation. The platform, made of polymethylmethacrylate (PMMA), allows real-time mechanical stimuli, providing valuable insights for living tissue models. Through mechanical testing and dynamic microfluidic tests, the chip functionality was assessed. The experimental results validation showcases the potential of the device in mimicking physiological conditions, offering a promising avenue for pharmaceutical testing advancement.

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Testa, M., Tornabene, S., Di Leonardo, S., Burriesci, G., La Carrubba, V., Lopresti, F.. 2023-12-15. Experimental Validation of an Organ-on-Chip for Mechanical Stimulation of Cell Cultures. https://doi.org/10.1101/2023.12.15.571835

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