'Pscore' - A Novel Percentile-Based Metric to Accurately Assess Individual Deviations in Non-Gaussian Distributions of Quantitative MRI Metrics

Abstract

BACKGROUNDQuantitative MRI metrics could be used in personalized medicine to assess individuals against normative distributions. Conventional Zscore analysis is inadequate in the presence of non-Gaussian distributions. Therefore, if quantitative MRI metrics deviate from normality, an alternative is needed. PURPOSETo confirm non-Gaussianity of diffusion MRI (dMRI) metrics on a publicly available dataset, and to propose a novel percentile-based method, Pscore to address this issue. STUDY TYPERetrospective cohort POPULATION961 healthy young-adults (age:22-35 years, Females:53%) from the Human Connectome Project FIELD STRENGTH/SEQUENCE3-T, spin-echo diffusion echo-planar imaging, T1-weighted: MPRAGE ASSESSMENTThe dMRI data were preprocessed using the TORTOISE pipeline. Forty-eight regions of interest (ROIs) from the JHU-atlas were redrawn on a study-specific diffusion tensor (DT) template and average values were computed from various DT and mean apparent propagator (MAP) metrics. For each ROI, percentile ranks across participants were computed to generate Pscores- which normalized the difference between the median and a participants value with the corresponding difference between the median and the 5th/95th percentile values. STATISTICAL TESTSROI-wise distributions were assessed using Log transformations, Zscore, and the Pscore methods. The percentages of extreme values above-95th and below-5th percentile boundaries (PEV>95(%),PEV<5(%)) were also assessed in the overall white matter. Bootstrapping was performed to test the reliability of Pscores in small samples (n=100) using 100 iterations. RESULTSThe dMRI metric distributions were systematically non-Gaussian, including positively skewed (e.g., mean and radial diffusivity) and negatively skewed (e.g., fractional and propagator anisotropy) metrics. This resulted in unbalanced tails in Zscore distributions (PEV>95=5%,PEV<5=5%) whereas Pscore distributions were symmetric and balanced (PEV>95=PEV<5=5%); even for small bootstrapped samples (average [Formula]. DATA CONCLUSIONThe inherent skewness observed for dMRI metrics may preclude the use of conventional Zscore analysis. The proposed Pscore method may help estimating individual deviations more accurately in skewed normative data, even from small datasets.