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bioRxiv · 10.1101/2023.12.04.569971

Auditory Aversive Generalization Learning Prompts Threat-Specific Changes in Alpha-Band Activity

Abstract

Pairing a neutral stimulus with aversive outcomes prompts neurophysiological and autonomic changes in response to the conditioned stimulus (CS+), compared to cues that signal safety (CS-). One of these changes--selective amplitude reduction of parietal alpha-band oscillations-- has been reliably linked to processing of visual CS+. It is however unclear to what extent auditory conditioned cues prompt similar changes, how these changes evolve as learning progresses, and how alpha reduction in the auditory domain generalizes to similar stimuli. To address these questions, fifty-five participants listened to three sine wave tones, with either the highest or lowest pitch (CS+) being associated with a noxious white noise burst. A threat specific (CS+) reduction in occipital-parietal alpha-band power was observed similar to changes expected for visual stimuli. No evidence for aversive generalization to the tone most similar to the CS+ was observed in terms of alpha-band power changes, aversiveness ratings, or pupil dilation. By-trial analyses found that selective alpha-band changes continued to increase as aversive conditioning continued, beyond when participants reported awareness of the contingencies. The results support a theoretical model in which selective alpha power represents a cross-modal index of continuous aversive learning, accompanied by sustained sensory discrimination of conditioned threat from safety cues.

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BibTeXRIS

Farkas, A. H., Ward, R. T., Gilbert, F. E., Pouliot, J., Chiasson, P., McIlvanie, S., Traiser, C., Riels, K., Mears, R., Keil, A.. 2023-12-06. Auditory Aversive Generalization Learning Prompts Threat-Specific Changes in Alpha-Band Activity. https://doi.org/10.1101/2023.12.04.569971

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