Four-Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage

Panten, J.; Del Prete, S.; Cleland, J. P.; Saunders, L. M.; van Riet, J.; Schneider, A.; Ginno, P. A.; Schneider, N.; Koch, M.-L.; Gerstung, M.; Stegle, O.; Turner, J. M. A.; Heard, E.; Odom, D. T.

doi:10.1101/2023.12.04.569933

bioRxiv · 10.1101/2023.12.04.569933

Four-Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage

Panten, J.·Del Prete, S.·Cleland, J. P.·Saunders, L. M.·van Riet, J.·Schneider, A.·Ginno, P. A.·Schneider, N.·Koch, M.-L.·Gerstung, M.·Stegle, O.·Turner, J. M. A.·Heard, E.·Odom, D. T.

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Abstract

The Four Core Genotypes (FCG) is a mouse model system heavily used to disentangle the function of sex chromosomes and hormones. We report that a copy of a 3.2 MB region of the X chromosome has translocated to the YSry- chromosome and thus increased the expression of multiple genes including the auto-immune master regulator Tlr7. This previously-unreported X-Y translocation complicates the interpretation of studies reliant on FCG mice.

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Panten, J., Del Prete, S., Cleland, J. P., Saunders, L. M., van Riet, J., Schneider, A., Ginno, P. A., Schneider, N., Koch, M.-L., Gerstung, M., Stegle, O., Turner, J. M. A., Heard, E., Odom, D. T.. 2023-12-05. Four-Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage. https://doi.org/10.1101/2023.12.04.569933

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