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bioRxiv · 10.1101/2023.12.01.569520

Dynamic changes in somatosensory and cerebellar activity mediate temporal recalibration of self-touch

Abstract

An organisms ability to accurately anticipate the sensations caused by its own actions is crucial for a wide range of behavioral, perceptual, and cognitive functions. Notably, the sensorimotor expectations produced when touching ones own body attenuate such sensations, making them feel weaker and less ticklish and rendering them easily distinguishable from potentially harmful touches of external origin. How the brain learns and keeps these action-related sensory expectations updated is unclear. We employed psychophysics and functional magnetic resonance imaging to pinpoint the behavioral and neural substrates of dynamic recalibration of expected temporal delays in self-touch. Psychophysical results revealed that self-touches were less attenuated after systematic exposure to delayed self-generated touches, while responses in the contralateral somatosensory cortex that normally distinguish between delayed and nondelayed self-generated touches became indistinguishable. During the exposure, the ipsilateral anterior cerebellum showed increased activity, supporting its proposed role in recalibrating sensorimotor predictions. Moreover, responses in the cingulate areas gradually increased, suggesting that as delay adaptation progresses, the nondelayed self-touches trigger activity related to cognitive conflict. Together, our results show that sensorimotor predictions in the simplest act of touching ones own body are upheld by a sophisticated and flexible neural mechanism that maintains them accurate in time.

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BibTeXRIS

Kilteni, K., Ehrsson, H. H.. 2023-12-04. Dynamic changes in somatosensory and cerebellar activity mediate temporal recalibration of self-touch. https://doi.org/10.1101/2023.12.01.569520

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