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bioRxiv · 10.1101/2023.11.28.569145

Coexpression enhances cross-species integration of scRNA-seq across diverse plant species

Passalacqua, M. J.·Gillis, J.
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Abstract

Single-cell RNA sequencing is increasingly used to investigate cross-species differences driven by gene expression and cell-type composition in plants. However, the frequent expansion of plant gene families due to whole genome duplications makes identification of one-to-one orthologs difficult, complicating integration. Here, we demonstrate that coexpression can be used to identify non-orthologous gene pairs with proxy expression profiles, improving the performance of traditional integration methods and reducing barriers to integration across a diverse array of plant species.

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Passalacqua, M. J., Gillis, J.. 2023-11-30. Coexpression enhances cross-species integration of scRNA-seq across diverse plant species. https://doi.org/10.1101/2023.11.28.569145

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