Human Heart Failure Alters Mitochondria and Fiber 3D Structure Triggering Metabolic Shifts

Vue, Z.; Ajayi, P. T.; Neikirk, K.; Murphy, A.; Prasad, P.; Jenkins, B. C.; Vang, L.; Garza-Lopez, E.; Mungai, M.; Marshall, A. G.; Beasley, H. K.; Killion, M.; Parker, R.; Anukodem, J.; Lavine, K.; Ajijola, O.; Mobley, B.; Dai, D.-F.; Exil, V.; Kirabo, A.; Ru Su, Y.; Tomasek, K.; Zhang, X.; Wanjalla, C. N.; Hubert, D. L.; Phillips, M. A.; McReynolds, M.; Glancy, B.; Hinton, A.

doi:10.1101/2023.11.28.569095

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bioRxiv · 10.1101/2023.11.28.569095

Human Heart Failure Alters Mitochondria and Fiber 3D Structure Triggering Metabolic Shifts

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Abstract

This study, utilizing SBF-SEM, reveals structural alterations in mitochondria and myofibrils in human heart failure (HF). Mitochondria in HF show changes in structure, while myofibrils exhibit increased cross-sectional area and branching. Metabolomic and lipidomic analyses indicate concomitant dysregulation in key pathways. The findings underscore the need for personalized treatments considering individualized structural changes in HF.

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Vue, Z., Ajayi, P. T., Neikirk, K., Murphy, A., Prasad, P., Jenkins, B. C., Vang, L., Garza-Lopez, E., Mungai, M., Marshall, A. G., Beasley, H. K., Killion, M., Parker, R., Anukodem, J., Lavine, K., Ajijola, O., Mobley, B., Dai, D.-F., Exil, V., Kirabo, A., Ru Su, Y., Tomasek, K., Zhang, X., Wanjalla, C. N., Hubert, D. L., Phillips, M. A., McReynolds, M., Glancy, B., Hinton, A.. 2023-11-30. Human Heart Failure Alters Mitochondria and Fiber 3D Structure Triggering Metabolic Shifts. https://doi.org/10.1101/2023.11.28.569095

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