The second messenger c-di-AMP controls natural competence via ComFB signaling protein

Samir, S.; Doello, S.; Zimmer, E.; Haffner, M.; Enkerlin, A. M.; Mueller, T.; Dengler, L.; Lambidis, S. P.; Sivabalasarma, S.; Albers, S.-V.; Selim, K. A.

doi:10.1101/2023.11.27.568819

bioRxiv · 10.1101/2023.11.27.568819

The second messenger c-di-AMP controls natural competence via ComFB signaling protein

Samir, S.·Doello, S.·Zimmer, E.·Haffner, M.·Enkerlin, A. M.·Mueller, T.·Dengler, L.·Lambidis, S. P.·Sivabalasarma, S.·Albers, S.-V.·Selim, K. A.

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Abstract

Natural competence requires a contractile pilus system. Here, we provide evidence that the pilus biogenesis and natural competence in cyanobacteria are regulated by the second messenger c-di-AMP. Furthermore, we show that the ComFB signaling protein is a novel c-di-AMP-receptor protein, widespread in bacterial phyla, and required for pilus biogenesis and DNA uptake.

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Samir, S., Doello, S., Zimmer, E., Haffner, M., Enkerlin, A. M., Mueller, T., Dengler, L., Lambidis, S. P., Sivabalasarma, S., Albers, S.-V., Selim, K. A.. 2023-11-27. The second messenger c-di-AMP controls natural competence via ComFB signaling protein. https://doi.org/10.1101/2023.11.27.568819

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