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bioRxiv · 10.1101/2023.11.21.568150

A tissue ubiquitous gene set for cellular senescence

Qu, Y.·Ji, Z.
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Abstract

Accurately identifying senescent cells is essential for studying their spatial and molecular features. We developed DeepScence, a method based on deep neural networks, to identify senescent cells in single-cell and spatial transcriptomics data. DeepScence is based on CoreScence, a senescence-associated gene set we curated that incorporates information from multiple published gene sets. We demonstrate that DeepScence can accurately identify senescent cells in single-cell gene expression data collected both in vitro and in vivo, as well as in spatial transcriptomics data generated by different platforms, substantially outperforming existing methods.

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Qu, Y., Ji, Z.. 2023-11-21. A tissue ubiquitous gene set for cellular senescence. https://doi.org/10.1101/2023.11.21.568150

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