Can non-invasive brain stimulation modulate peak alpha frequency in the human brain? A systematic review and meta-analysis

Millard, S. K.; Speis, D. B.; Skippen, P.; Chiang, A. K. I.; Chang, W.-J.; Lin, A. J.; Furman, A.; Mazaheri, A.; Seminowicz, D. A.; Schabrun, S.

doi:10.1101/2023.11.13.566909

bioRxiv · 10.1101/2023.11.13.566909

Can non-invasive brain stimulation modulate peak alpha frequency in the human brain? A systematic review and meta-analysis

Millard, S. K.·Speis, D. B.·Skippen, P.·Chiang, A. K. I.·Chang, W.-J.·Lin, A. J.·Furman, A.·Mazaheri, A.·Seminowicz, D. A.·Schabrun, S.

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Abstract

Peak alpha frequency, the dominant oscillatory frequency within the alpha range (8-12 Hz), is associated with cognitive function and several neurological conditions, including chronic pain. Manipulating PAF could offer valuable insight into the relationship between PAF and various functions and conditions and provide new treatment avenues. This systematic review aimed to comprehensively synthesise effects of non-invasive brain stimulation (NIBS) on PAF speed. Relevant studies assessing PAF pre- and post-NIBS in healthy adults were identified through systematic searches of electronic databases (Embase, PubMed, PsychINFO, Scopus, The Cochrane Library) and trial registers. The Cochrane risk-of-bias tool was employed for assessing study quality. Quantitative analysis was conducted through pairwise meta-analysis when possible; otherwise, qualitative synthesis was performed. The review protocol was registered with PROSPERO (CRD42020190512) and the Open Science Framework (https://osf.io/2yaxz/). Eleven NIBS studies were included, all with a low risk-of-bias, comprising seven transcranial alternating current stimulation (tACS), three repetitive transcranial magnetic stimulation (rTMS), and one transcranial direct current stimulation (tDCS) study. Meta-analysis of active tACS conditions (eight conditions from five studies) revealed no significant effects on PAF (mean difference [MD] = -0.12, 95% CI = -0.32 to 0.08, p = 0.24). Qualitative synthesis provided no evidence that tDCS altered PAF and moderate evidence for transient increases in PAF with 10 Hz rTMS. There is limited evidence that NIBS can modulate PAF, and existing evidence does not demonstrate robust effects. Further studies employing standardised stimulation protocols are necessary to determine the potential of NIBS to modulate PAF.

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Millard, S. K., Speis, D. B., Skippen, P., Chiang, A. K. I., Chang, W.-J., Lin, A. J., Furman, A., Mazaheri, A., Seminowicz, D. A., Schabrun, S.. 2023-11-16. Can non-invasive brain stimulation modulate peak alpha frequency in the human brain? A systematic review and meta-analysis. https://doi.org/10.1101/2023.11.13.566909

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