MIOSTONE: Modeling microbiome-trait associations withtaxonomy-adaptive neural networks

Jiang, Y.; Atton, M.; Zhu, Q.; Lu, Y.

doi:10.1101/2023.11.04.565596

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bioRxiv · 10.1101/2023.11.04.565596

MIOSTONE: Modeling microbiome-trait associations withtaxonomy-adaptive neural networks

Jiang, Y.·Atton, M.·Zhu, Q.·Lu, Y.

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Abstract

AbstractThe human microbiome, a complex ecosystem of microorganisms inhabiting the body, plays a critical role in human health. Investigating its association with host traits is essential for understanding its impact on various diseases. Although shotgun metagenomic sequencing technologies have produced vast amounts of microbiome data, analyzing such data is highly challenging due to its sparsity, noisiness, and high feature dimensionality. Here we develop MIOSTONE, an accurate and interpretable neural network model for microbiome-disease association that simulates a real taxonomy by encoding the relationships among microbial features. The taxonomy-encoding architecture provides a natural bridge from variations in microbial taxa abundance to variations in traits, encompassing increasingly coarse scales from species to domains. MIOSTONE has the ability to determine whether taxa within the corresponding taxonomic group provide a better explanation in a data-driven manner. MIOSTONE serves as an effective predictive model, as it not only accurately predicts microbiome-trait associations across extensive simulated and real datasets but also offers interpretability for scientific discovery. Both attributes are crucial for facilitating in silico investigations into the biological mechanisms underlying such associations among microbial taxa.

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Jiang, Y., Atton, M., Zhu, Q., Lu, Y.. 2023-11-05. MIOSTONE: Modeling microbiome-trait associations withtaxonomy-adaptive neural networks. https://doi.org/10.1101/2023.11.04.565596

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