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bioRxiv · 10.1101/2023.10.26.564293

Deep-Learning-Enabled Differentiation between Intraprostatic Gold Fiducial Markers and Calcification in Quantitative Susceptibility Mapping

Abstract

PurposeInterest is growing in MR-only radiotherapy (RT) planning for prostate cancer (PCa) due to the potential reductions in cost and patient exposure to radiation, and a more streamlined work-flow and patient imaging pathway. However, in MRI, the gold fiducial markers (FMs) used for target localization appear as signal voids, complicating differentiation from other void sources such as calcifications and bleeds. This work investigates using Quantitative Susceptibility Mapping (QSM), an MRI phase post-processing technique, to aid in the differentiation task. It also presents deep learning models that capture nuanced information and automate the segmentation task, facilitating a streamlined approach to MR-only RT. MethodsCT and MRI, including GRE and T1-weighted imaging, were acquired from 26 PCa patients, each with three implanted gold FMs. GRE data were post-processed into QSM, T 2*, and R2* maps using QSMxTs body imaging pipeline. Statistical analyses were conducted to investigate the quantitative differentiation of FMs and calcification in each contrast. 3D U-Nets were developed using fastMONAI to automate the segmentation task using various combinations of MR-derived contrasts, with a model trained on CT used as a baseline. Models were evaluated using precision and recall calculated using a leave-one-out cross-validation scheme. ResultsSignificant differences were observed between FM and calcification regions in CT, QSM and T 2*, though overlap was observed in QSM and T 2*. The baseline CT U-Net achieved an FM-level precision of {approx} 98% and perfect recall. The best-performing QSM-based model achieved precision and recall of 80% and 90%, respectively, while conventional MRI had values below 70% and 80%, respectively. The QSM-based model produced segmentations with good agreement with the ground truth, including a challenging FM that coincided with a bleed. ConclusionThe model performance highlights the value of using QSM over indirect measures in MRI, such as signal voids in magnitude-based contrasts. The results also indicate that a U-Net can capture more information about the presentation of FMs and other sources than would be possible using susceptibility quantification alone, which may be less reliable due to the diverse presentation of sources across a patient population. In our study, QSM was a reliable discriminator of FMs and other sources in the prostate, facilitating an accurate and streamlined approach to MR-only RT.

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Stewart, A. W., Goodwin, J., Richardson, M., Robinson, S. D., O'Brien, K., Jin, J., Barth, M., Bollmann, S.. 2023-10-31. Deep-Learning-Enabled Differentiation between Intraprostatic Gold Fiducial Markers and Calcification in Quantitative Susceptibility Mapping. https://doi.org/10.1101/2023.10.26.564293

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