Not all Bacterial Outer-membrane Proteins are β-Barrels

Heido, J.; Keng, S.; Poyrazoglu, H.; Priyam, E.; Jayasinghe, S.

doi:10.1101/2023.10.25.564060

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bioRxiv · 10.1101/2023.10.25.564060

Not all Bacterial Outer-membrane Proteins are β-Barrels

Heido, J.·Keng, S.·Poyrazoglu, H.·Priyam, E.·Jayasinghe, S.

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Abstract

The discovery of WzA, an octomeric helical barrel integral bacterial outer membrane protein, has challenged the widely held understanding that all integral outer membrane proteins of gram-negative bacteria are closed {beta}-barrels composed of transmembrane {beta}-strands. WzA is a member of the outer membrane polysaccharide exporter family and a bioinformatics analysis suggests that other members of the family may also contain outer membrane transmembrane segments that are helical. A review of the literature indicates that in addition to Wza, outer membrane core complex proteins of the type IV secretion systems also contain transmembrane segments that are helical.

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Heido, J., Keng, S., Poyrazoglu, H., Priyam, E., Jayasinghe, S.. 2023-10-28. Not all Bacterial Outer-membrane Proteins are β-Barrels. https://doi.org/10.1101/2023.10.25.564060

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