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bioRxiv · 10.1101/2023.10.25.563898

A natural cyclic peptide valinomycin enhances plant innate immunity

Yoo, N.·Kang, J. E.·Kim, D.-R.·Lee, H.·Ko, D.·Kwak, Y.-S.·Chung, E.-H.
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Abstract

Various natural compounds as alternative agents for the chemical management of plant diseases have long been proposed. Valinomycin, a Streptomyces-derived cyclic peptide, acts as an antifungal agent against several plant pathogenic fungi, including Botrytis cinerea. Here, we report the novel function of valinomycin, plant immune-boosting. Valinomycin potentiates pattern-triggered immunity (PTI) and effector-triggered immunity (ETI) in Arabidopsis, leading to enhanced resistance against bacterial speck disease locally and systemically. Moreover, this plant immune-boosting activity of valinomycin is associated with plant hormonal signaling. Thus, we propose that valinomycin harbors potential as a biocontrol agent suppressing complex pathogen infections, such as bacteria and fungi.

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Yoo, N., Kang, J. E., Kim, D.-R., Lee, H., Ko, D., Kwak, Y.-S., Chung, E.-H.. 2023-10-27. A natural cyclic peptide valinomycin enhances plant innate immunity. https://doi.org/10.1101/2023.10.25.563898

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