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bioRxiv · 10.1101/2023.10.23.563030

Distinct eLPB ChAT projections for methamphetamine anxiety and relapse

Chen, W.·Guo, H.·Zhou, N.·Xu, X.·Mai, Y.·He, T.·Wen, J.·Ge, F.·Qin, S.·Liu, C.·Wu, W.·Kim, H. Y.·Fan, Y.·Guan, X.
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Abstract

Choline acetyltransferase-positive neurons in the external lateral parabrachial nucleus (eLPBChAT) send projections to PKC{delta}-positive (PKC{delta}+) neurons in lateral portion of central nucleus of amygdala (lCeAPKC{delta}) and oval portion of bed nucleus of the stria terminalis (ovBNSTPKC{delta}), forming eLPBChAT-lCeAPKC{delta} and eLPBChAT-ovBNSTPKC{delta} pathways. At least in part, the eLPBChAT neurons positively innervate lCeAPKC{delta} and ovBNSTPKC{delta} through regulating synaptic elements of presynaptic acetylcholine (Ach) release and postsynaptic nicotinic acetylcholine receptors (nAChRs). Methamphetamine (METH) withdrawal anxiety and METH-primed reinstatement of conditioned place preference (CPP) recruit eLPBChAT-lCeAPKC{delta} pathway and eLPBChAT-ovBNSTPKC{delta} pathway in male METH-exposed mice, respectively.

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Chen, W., Guo, H., Zhou, N., Xu, X., Mai, Y., He, T., Wen, J., Ge, F., Qin, S., Liu, C., Wu, W., Kim, H. Y., Fan, Y., Guan, X.. 2023-10-23. Distinct eLPB ChAT projections for methamphetamine anxiety and relapse. https://doi.org/10.1101/2023.10.23.563030

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