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bioRxiv · 10.1101/2023.10.16.562624

Study on the preparation of bovine milk exosomes and the stability of lyophilized powder

Ge, X.·Li, T.·Lu, L.·Han, C.·Wang, M.·Du, H.·Chen, N.·Gao, M.·Wang, N.·Qi, D.·Bai, W.·Yin, J.·Dong, F.
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Abstract

Bovune milk exosomes (MK-exo) have bioactive effects on the health of consumers and can also serve as excellent drug delivery vehicles. However, long-term preservation and transportation remain major challenges at present. In this report, high-quality MK-exo are prepared on a large scale. We then developed a lyophilization method belonging to MK-exo, and performed acceleration and long-term stability experiments on the lyophilized MK-exo to evaluate the effect of lyophilization. The results showed that the lyophilized MK-exo can be stored at room temperature for at least 3 months and 2-8{degrees}C for 15 months. These findings provide data support for further understanding of the properties and applications of MK-exo.

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Ge, X., Li, T., Lu, L., Han, C., Wang, M., Du, H., Chen, N., Gao, M., Wang, N., Qi, D., Bai, W., Yin, J., Dong, F.. 2023-10-19. Study on the preparation of bovine milk exosomes and the stability of lyophilized powder. https://doi.org/10.1101/2023.10.16.562624

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