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bioRxiv · 10.1101/2023.10.06.560797

Reply to: Commentary on Pang et al. (2023) Nature

Pang, J. C.·Aquino, K. M.·Oldehinkel, M.·Robinson, P. A.·Fulcher, B. D.·Breakspear, M.·Fornito, A.
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Abstract

In Pang et al. (2023)1, we identified a close link between the geometry and function of the human brain by showing that: (1) eigenmodes derived from cortical geometry parsimoniously reconstruct activity patterns recorded with functional magnetic resonance imaging (fMRI); (2) task-evoked cortical activity results from excitations of brain-wide modes with long wavelengths; (3) wave dynamics, constrained by geometry and distance-dependent connectivity, can account for diverse aspects of spontaneous and evoked brain activity; and (4) geometry and function are strongly coupled in the subcortex. Faskowitz et al. (2023)2 raise concerns about the framing of our paper and the specificity of the eigenmode reconstructions in result (1). Here, we address these concerns and show how specificity is established by using appropriate benchmarks.

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Pang, J. C., Aquino, K. M., Oldehinkel, M., Robinson, P. A., Fulcher, B. D., Breakspear, M., Fornito, A.. 2023-10-09. Reply to: Commentary on Pang et al. (2023) Nature. https://doi.org/10.1101/2023.10.06.560797

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