Genetic Variants That Modify the Neuroendocrine Regulation of Foraging Behavior in C. elegans

Lee, H.; Boor, S. A.; Hilbert, Z. A.; Meisel, J. D.; Park, J.; Wang, Y.; McKeown, R. J.; Fischer, S.; Andersen, E. C.; Kim, D. H.

doi:10.1101/2023.09.09.556976

bioRxiv · 10.1101/2023.09.09.556976

Genetic Variants That Modify the Neuroendocrine Regulation of Foraging Behavior in C. elegans

Lee, H.·Boor, S. A.·Hilbert, Z. A.·Meisel, J. D.·Park, J.·Wang, Y.·McKeown, R. J.·Fischer, S.·Andersen, E. C.·Kim, D. H.

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Abstract

The molecular mechanisms underlying diversity in animal behavior are not well understood. A major experimental challenge is determining the contribution of genetic variants that affect neuronal gene expression to differences in behavioral traits. The neuroendocrine TGF-beta ligand, DAF-7, regulates diverse behavioral responses of Caenorhabditis elegans to bacterial food and pathogens. The dynamic neuron-specific expression of daf-7 is modulated by environmental and endogenous bacteria-derived cues. Here, we investigated natural variation in the expression of daf-7 from the ASJ pair of chemosensory neurons and identified common variants in gap-2, encoding a GTPase-Activating Protein homologous to mammalian SynGAP proteins, which modify daf-7 expression cell-non-autonomously and promote exploratory foraging behavior in a DAF-7-dependent manner. Our data connect natural variation in neuron-specific gene expression to differences in behavior and suggest that genetic variation in neuroendocrine signaling pathways mediating host-microbe interactions may give rise to diversity in animal behavior.

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Lee, H., Boor, S. A., Hilbert, Z. A., Meisel, J. D., Park, J., Wang, Y., McKeown, R. J., Fischer, S., Andersen, E. C., Kim, D. H.. 2023-09-12. Genetic Variants That Modify the Neuroendocrine Regulation of Foraging Behavior in C. elegans. https://doi.org/10.1101/2023.09.09.556976

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