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bioRxiv · 10.1101/2023.09.05.556301

CBGTPy: An extensible cortico-basal ganglia-thalamic framework for modeling biological decision making

Abstract

Here we introduce CBGTPy, a virtual environment for designing and testing goal-directed agents with internal dynamics that are modeled on the cortico-basal-ganglia-thalamic (CBGT) pathways in the mammalian brain. CBGTPy enables researchers to investigate the internal dynamics of the CBGT system during a variety of tasks, allowing for the formation of testable predictions about animal behavior and neural activity. The framework has been designed around the principle of flexibility, such that many experimental parameters in a decision making paradigm can be easily defined and modified. Here we demonstrate the capabilities of CBGTPy across a range of single and multi-choice tasks, highlighting the ease of set up and the biologically realistic behavior that it produces. We show that CBGTPy is extensible enough to apply to a range of experimental protocols and to allow for the implementation of model extensions with minimal developmental effort. Author summaryWe introduce a toolbox for producing biologically realistic simulations of the cortico-basal ganglia-thalamic dynamics during a variety of experimental tasks. The purpose is to foster the theory-experiment cycle, offering a tool for generating testable predictions of behavioral and neural responses that can be validated experimentally, in a framework that allows for simple updating as new experimental evidence emerges. We outline how our toolbox works and demonstrate its performance on a set of normative cognitive tasks.

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BibTeXRIS

Clapp, M., Bahuguna, J., Giossi, C., Rubin, J., Verstynen, T. V., Vich, C.. 2023-09-05. CBGTPy: An extensible cortico-basal ganglia-thalamic framework for modeling biological decision making. https://doi.org/10.1101/2023.09.05.556301

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