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bioRxiv · 10.1101/2023.08.27.552978

Travelling waves or sequentially activated discrete modules: mapping the granularity of cortical propagation

Abstract

Numerous studies have identified travelling waves in the cortex and suggested they play important roles in brain processing. These waves are most often measured using macroscopic methods that are unable to assess the local spiking activity underlying wave dynamics. Here we investigated the possibility that waves may not be travelling at the single neuron scale. We first show that sequentially activating two discrete brain areas can appear as travelling waves in EEG simulations. We next reproduce these results using an analytical model of two sequentially activated regions. Using this model, we were able to generate wave-like activity with variable directions, velocities, and spatial patterns, and to map the discriminability limits between travelling waves and modular sequential activations. Finally, we investigated the link between field potentials and single neuron excitability using large-scale measurements from turtle cortex ex-vivo. We found that while field potentials exhibit wave-like dynamics, the underlying spiking activity was better described by consecutively activated spatially adjacent groups of neurons. Taken together, this study suggests caution when interpreting phase delay measurements as continuously propagating wavefronts in two different spatial scales. A careful distinction between modular and wave excitability profiles across scales will be critical for understanding the nature of cortical computations.

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Orsher, Y., Rom, A., Perel, R., Lahini, Y., Blinder, P., Shein-Idelson, M.. 2023-08-28. Travelling waves or sequentially activated discrete modules: mapping the granularity of cortical propagation. https://doi.org/10.1101/2023.08.27.552978

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