Effects of nicotine compared to placebo gum on sensitivity to pain and mediating effects of peak alpha frequency

Millard, S. K.; Chiang, A. K.; Humburg, P.; Chowdhury, N.; Rehan, R.; Furman, A. J.; Mazaheri, A.; Schabrun, S. M.; Seminowicz, D. A.

doi:10.1101/2023.08.11.552723

bioRxiv · 10.1101/2023.08.11.552723

Effects of nicotine compared to placebo gum on sensitivity to pain and mediating effects of peak alpha frequency

Millard, S. K.·Chiang, A. K.·Humburg, P.·Chowdhury, N.·Rehan, R.·Furman, A. J.·Mazaheri, A.·Schabrun, S. M.·Seminowicz, D. A.

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Abstract

Recent research has linked individual peak alpha frequency (PAF) to pain sensitivity, but whether PAF alterations can influence pain remains unclear. Our study investigated the effects of nicotine on pain sensitivity and whether pain changes are mediated by PAF changes. In a randomised, double-blind, placebo-controlled experiment, 62 healthy adults (18-44 years) received either 4 mg nicotine (n=29) or placebo gum (n=33). Resting state EEG and pain ratings during prolonged heat and pressure models were collected before and after nicotine intake. The nicotine group showed a small decrease in heat-pain ratings compared to placebo group when controlling confounders, and a small increase in PAF across the scalp from pre- to post-gum, both with and without confounder adjustment. These effects were most pronounced in the central-parietal and right-frontal electrodes. However, mediation analysis did not support the notion that PAF changes mediate nicotines effects on pain sensitivity. While a growing body of literature supports a link between PAF and both acute and chronic pain, further work is needed to understand the mechanisms of this link.

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Millard, S. K., Chiang, A. K., Humburg, P., Chowdhury, N., Rehan, R., Furman, A. J., Mazaheri, A., Schabrun, S. M., Seminowicz, D. A.. 2023-08-14. Effects of nicotine compared to placebo gum on sensitivity to pain and mediating effects of peak alpha frequency. https://doi.org/10.1101/2023.08.11.552723

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