Decoding auditory working memory content from intracranial high frequency activity in humans

Uluc, I.; Peled, N.; Paulk, A. C.; Bush, A.; Gumenyuk, V.; Kotlarz, P. L.; Lankinen, K.; Mamashli, F.; Matsuda, N.; Richardson, M.; Stufflebeam, S. M.; Cash, S. S.; Ahveninen, J.

doi:10.1101/2023.08.04.552073

bioRxiv · 10.1101/2023.08.04.552073

Decoding auditory working memory content from intracranial high frequency activity in humans

Uluc, I.·Peled, N.·Paulk, A. C.·Bush, A.·Gumenyuk, V.·Kotlarz, P. L.·Lankinen, K.·Mamashli, F.·Matsuda, N.·Richardson, M.·Stufflebeam, S. M.·Cash, S. S.·Ahveninen, J.

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Abstract

Working memory (WM), the human brains system for maintaining and manipulating information over short timescales, is critical for goal-directed behavior. Classic neurophysiological models, which emphasize persistent delay activity, are being challenged by an idea that WM is maintained through dynamic and activity-silent mechanisms, where the memory trace is preserved by transient changes in the connections between neurons. To date, human evidence for this alternative model has been limited to non-invasive studies. Here, leveraging high-resolution intracranial stereo-EEG with advanced machine learning decoding techniques, we investigate neuronal mechanisms of human auditory WM. Neuronal activity is quantified as broadband high frequency activity (70-190 Hz), a correlate of neuronal firing activity. Our multivariate pattern analyses, validated via robust non-parametric permutation testing, show that WM content is represented in multiple brain regions, exhibiting dynamic rather than persistent delay activity. Crucially, by using task-irrelevant sounds to probe latent mnemonic states, we provide the first human intracranial evidence of activity silent WM maintenance in a local sensory network.

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Uluc, I., Peled, N., Paulk, A. C., Bush, A., Gumenyuk, V., Kotlarz, P. L., Lankinen, K., Mamashli, F., Matsuda, N., Richardson, M., Stufflebeam, S. M., Cash, S. S., Ahveninen, J.. 2023-08-07. Decoding auditory working memory content from intracranial high frequency activity in humans. https://doi.org/10.1101/2023.08.04.552073

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