Spontaneous enteric nervous system activity precedes maturation of gastrointestinal motility

Dershowitz, L. B.; Garcia, H. B.; Perley, A. S.; Coleman, T. P.; Kaltschmidt, J. A.

doi:10.1101/2023.08.03.551847

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bioRxiv · 10.1101/2023.08.03.551847

Spontaneous enteric nervous system activity precedes maturation of gastrointestinal motility

Dershowitz, L. B.·Garcia, H. B.·Perley, A. S.·Coleman, T. P.·Kaltschmidt, J. A.

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Abstract

Spontaneous neuronal network activity is essential in development of central and peripheral circuits, yet whether this is a feature of enteric nervous system development has yet to be established. Using ex vivo gastrointestinal (GI) motility assays with unbiased computational analyses, we identify a previously unknown pattern of spontaneous neurogenic GI motility. We further show that this motility is driven by cholinergic signaling, which may inform GI pharmacology for preterm patients.

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Dershowitz, L. B., Garcia, H. B., Perley, A. S., Coleman, T. P., Kaltschmidt, J. A.. 2023-08-06. Spontaneous enteric nervous system activity precedes maturation of gastrointestinal motility. https://doi.org/10.1101/2023.08.03.551847

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