Salmonella Infantis, the emerging human multidrug resistant pathogen - a One Health perspective

Mattock, J.; Chattaway, M. A.; Hartman, H.; Dallman, T.; Smith, A.; Keddy, K.; Petrovska, L.; Manners, E.; Duze, S.; Smouse, S.; Tau, N. P.; Timme, R.; Baker, D.; Mather, A.; Wain, J.; Langridge, G.

doi:10.1101/2023.07.28.549231

bioRxiv · 10.1101/2023.07.28.549231

Salmonella Infantis, the emerging human multidrug resistant pathogen - a One Health perspective

Mattock, J.·Chattaway, M. A.·Hartman, H.·Dallman, T.·Smith, A.·Keddy, K.·Petrovska, L.·Manners, E.·Duze, S.·Smouse, S.·Tau, N. P.·Timme, R.·Baker, D.·Mather, A.·Wain, J.·Langridge, G.

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Abstract

Salmonella Infantis presents an ever-increasing threat to public health due to its spread throughout many countries and association with high levels of antimicrobial resistance (AMR). Whole genome sequences of 5,284 S. Infantis strains from 74 countries, isolated between 1989 and 2020 from a wide variety of sources including humans, animals, and food, were analysed to compare genetic phylogeny, AMR determinants and plasmid presence. The global S. Infantis population structure diverged into three clusters: a North American cluster, European cluster and a global cluster. The levels of AMR varied between the S. Infantis clusters and by isolation source; 73% of poultry isolates had multidrug resistance (MDR) compared to 35% of human isolates. This correlated with plasmid of emerging S. Infantis (pESI) presence; 71% of poultry isolates contained pESI versus 32% of human isolates. This provides important information for public health teams engaged in reducing the spread of this pathogen.

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Mattock, J., Chattaway, M. A., Hartman, H., Dallman, T., Smith, A., Keddy, K., Petrovska, L., Manners, E., Duze, S., Smouse, S., Tau, N. P., Timme, R., Baker, D., Mather, A., Wain, J., Langridge, G.. 2023-07-31. Salmonella Infantis, the emerging human multidrug resistant pathogen - a One Health perspective. https://doi.org/10.1101/2023.07.28.549231

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