DSPE-PEG-CeO2 inhibits tumor cell proliferation by inducing oxidative stress and cell death

Hao, Q. S.; Fang, J. Y.; Yao, W. X.; Huan, L.

doi:10.1101/2023.07.26.550631

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bioRxiv · 10.1101/2023.07.26.550631

DSPE-PEG-CeO2 inhibits tumor cell proliferation by inducing oxidative stress and cell death

Hao, Q. S.·Fang, J. Y.·Yao, W. X.·Huan, L.

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Abstract

SUMMARYCeO2 can consume intracellular reducing power, but its poor biocompatibility limits its application in tumor therapy. In this study, we designed and synthesized DSPE-PEG-CeO2, which is easy to enter cells, and showed that DSPE-PEG-CeO2 can induce the increase of ROS levels in tumor cells, thereby inducing tumor cell apoptosis and DNA damage. This suppresses the appearance and development of tumor cells. This provides a new idea for the application of inorganic nanomaterials.

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Hao, Q. S., Fang, J. Y., Yao, W. X., Huan, L.. 2023-07-27. DSPE-PEG-CeO2 inhibits tumor cell proliferation by inducing oxidative stress and cell death. https://doi.org/10.1101/2023.07.26.550631

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