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bioRxiv · 10.1101/2023.07.24.550424

A Bayesian Regularized and Anotation-Informed Integrative Analysis of Cognition (BRAINIAC)

Zablocki, R.·Xu, B.·Fan, C.·Thompson, W. K.
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Abstract

1Here we present a development of the novel Bayesian Regularized and Anotation-Informed Integrative Analysis of Cognition (BRAINIAC) model. BRAINIAC allows for both estimation of total variance explained by all features for a given cognitive phenotype, as well as a principled assessment of the impact of annotations on relative enrichment of features compared to others in terms of variance explained, without relying on a potentially unrealistic assumption of sparsity of brain-cognition associations. We apply the BRAINIAC model to resting state fMRI data from the Adolescent Brain Cognitive Development Study.

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Zablocki, R., Xu, B., Fan, C., Thompson, W. K.. 2023-07-26. A Bayesian Regularized and Anotation-Informed Integrative Analysis of Cognition (BRAINIAC). https://doi.org/10.1101/2023.07.24.550424

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