Functional Connectivity Development along the Sensorimotor-Association Axis Enhances the Cortical Hierarchy

Luo, A.; Sydnor, V. J.; Pines, A.; Larsen, B.; Alexander-Bloch, A. F.; Cieslak, M.; Covitz, S.; Chen, A.; Esper, N. B.; Feczko, E.; Franco, A. R.; Gur, R. E.; Gur, R. C.; Houghton, A.; Hu, F.; Keller, A. S.; Kiar, G.; Mehta, K.; Salum, G. A.; Tapera, T.; Xu, T.; Zhao, C.; Fair, D. A.; Salo, T.; Shinohara, R. T.; Milham, M. P.; Satterthwaite, T. D.

doi:10.1101/2023.07.20.549090

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bioRxiv · 10.1101/2023.07.20.549090

Functional Connectivity Development along the Sensorimotor-Association Axis Enhances the Cortical Hierarchy

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Abstract

Human cortical maturation has been posited to be organized along the sensorimotor-association (S-A) axis, a hierarchical axis of brain organization that spans from unimodal sensorimotor cortices to transmodal association cortices. Here, we investigate the hypothesis that the development of functional connectivity during childhood through adolescence conforms to the cortical hierarchy defined by the S-A axis. We tested this pre-registered hypothesis in four large-scale, independent datasets (total n = 3,355; ages 5-23 years): the Philadelphia Neurodevelopmental Cohort (n = 1,207), Nathan Kline Institute-Rockland Sample (n = 397), Human Connectome Project: Development (n = 625), and Healthy Brain Network (n = 1,126). In each dataset, the development of functional connectivity systematically varied along the S-A axis. Connectivity in sensorimotor regions increased, whereas connectivity in association cortices declined, refining and reinforcing the cortical hierarchy. These robust and generalizable results establish that the sensorimotor-association axis of cortical organization encodes the dominant pattern of functional connectivity development.

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Luo, A., Sydnor, V. J., Pines, A., Larsen, B., Alexander-Bloch, A. F., Cieslak, M., Covitz, S., Chen, A., Esper, N. B., Feczko, E., Franco, A. R., Gur, R. E., Gur, R. C., Houghton, A., Hu, F., Keller, A. S., Kiar, G., Mehta, K., Salum, G. A., Tapera, T., Xu, T., Zhao, C., Fair, D. A., Salo, T., Shinohara, R. T., Milham, M. P., Satterthwaite, T. D.. 2023-07-25. Functional Connectivity Development along the Sensorimotor-Association Axis Enhances the Cortical Hierarchy. https://doi.org/10.1101/2023.07.20.549090

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