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bioRxiv · 10.1101/2023.07.19.549365

A neuropsychological basis for temptation-resistant voluntary exercise

Tesmer, A. L.·Li, X.·Schmandt, C.·Polania, R.·Peleg-Raibstein, D.·Burdakov, D.
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Abstract

Despite well-known health benefits of physical activity, many people under-exercise, and what drives prioritization of exercise over other alternatives is unclear. We implement a novel paradigm allowing to study how freely behaving mice rapidly display such prioritizing between time spent on wheel-running and other temptations such as palatable food. Causal manipulations and correlative analyses of underlying appetitive and consummatory psychobehavioral processes revealed this prioritizing to be instantiated by hypothalamic hypocretin/orexin neurons.

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Tesmer, A. L., Li, X., Schmandt, C., Polania, R., Peleg-Raibstein, D., Burdakov, D.. 2023-07-19. A neuropsychological basis for temptation-resistant voluntary exercise. https://doi.org/10.1101/2023.07.19.549365

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