In vivo marker of brainstem myelin is associated to quantitative sleep parameters in healthy young men

Talwar, P.; Deantoni, M. A.; Van Egroo, M.; Muto, V.; Chylinski, D.; Koshmanova, E.; Jaspar, M.; Meyer, C.; Degueldre, C.; Berthomier, C.; Luxen, A.; Salmon, E.; Collette, F.; Dijk, D.-J.; Schmidt, C.; Phillips, C.; Maquet, P.; Sherif, S.; Vandewalle, G.

doi:10.1101/2023.07.17.549285

bioRxiv · 10.1101/2023.07.17.549285

In vivo marker of brainstem myelin is associated to quantitative sleep parameters in healthy young men

Talwar, P.·Deantoni, M. A.·Van Egroo, M.·Muto, V.·Chylinski, D.·Koshmanova, E.·Jaspar, M.·Meyer, C.·Degueldre, C.·Berthomier, C.·Luxen, A.·Salmon, E.·Collette, F.·Dijk, D.-J.·Schmidt, C.·Phillips, C.·Maquet, P.·Sherif, S.·Vandewalle, G.

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Abstract

Brain structural integrity has been suggested to contribute to the variability in human sleep quality and composition. The associations between sleep parameters and the regional integrity of subcortical structures implicated in sleep-wake regulation remain, however, largely unexplored. The present study aimed at assessing association between quantitative Magnetic Resonance Imaging (qMRI)-derived marker of the myelin content of the brainstem with the variability in the sleep electrophysiology in a large sample of healthy young men (N=321;[~]22y). Generalized Additive Model for Location, Scale and Shape (GAMLSS) was used to seek associations between sleep metrics and Magnetisation Transfer saturation (MTsat) qMRI values, proxy for myelin content. Separate GAMLSS revealed that sleep onset latency and slow wave sleep intensity were significantly associated with MTsat-derived myelin estimates in the brainstem (pcorrected[≤].03), with overall higher MTsat value associated with values reflecting better sleep quality. The association changed with age, however (MTsat-by-age interaction - pcorrected[≤].03), with higher MTsat value linked to better values in the two sleep metrics in the individuals of our sample aged [~]18 to 20y. Similar associations were detected across different parts of the brainstem (pcorrected[≤].03), suggesting that the overall maturation and integrity of the brainstem was associated with both sleep metrics. Our results suggest that myelination of the many reticular nuclei of the brainstem essential to regulation of sleep is associated with inter-individual differences in sleep characteristics during early adulthood. They may have implications for sleep disorders or neurological diseases related to myelin.

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Talwar, P., Deantoni, M. A., Van Egroo, M., Muto, V., Chylinski, D., Koshmanova, E., Jaspar, M., Meyer, C., Degueldre, C., Berthomier, C., Luxen, A., Salmon, E., Collette, F., Dijk, D.-J., Schmidt, C., Phillips, C., Maquet, P., Sherif, S., Vandewalle, G.. 2023-07-18. In vivo marker of brainstem myelin is associated to quantitative sleep parameters in healthy young men. https://doi.org/10.1101/2023.07.17.549285

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