Longstanding auditory sensory and semantic differences in preterm born children

Abstract

More than 10% of births are preterm, and the long-term consequences on sensory and semantic processing of non-linguistic information remain poorly understood. 17 very preterm-born children (born at <33 weeks gestational age) and 15 full-term controls were tested at 10 years old with an auditory object recognition task, while 64-channel auditory evoked potentials (AEPs) were recorded. Sounds consisted of living (animal and human vocalizations) and manmade objects (e.g. household objects, instruments, and tools). Despite similar recognition behavior, AEPs strikingly differed between full-term and preterm children. Starting at 50ms post-stimulus onset, AEPs from preterm children differed topographically from their full-term counterparts. Over the 108-224ms post-stimulus period, full-term children showed stronger AEPs in response to living objects, whereas preterm born children showed the reverse pattern; i.e. stronger AEPs in response to manmade objects. Differential brain activity between semantic categories could reliably classify children according to their preterm status. Moreover, this opposing pattern of differential responses to semantic categories of sounds was also observed in source estimations within a network of occipital, temporal and frontal regions. This study highlights how early life experience in terms of preterm birth shapes sensory and object processing later on in life. HighlightsO_LIHow very preterm birth affects nonlinguistic auditory processes in school-age is unknown C_LIO_LIWe measured auditory evoked potentials to environmental sounds C_LIO_LISensory processing differences manifested from 50ms post-stimulus onwards C_LIO_LISemantic processing differences manifested at 108-224ms post-stimulus C_LIO_LIClassification of preterm status was possible from semantic processing differences C_LI