A growth chart of brain function from infancy to adolescence based on electroencephalography

Abstract

BackgroundIn children, objective, quantitative tools that determine functional neurodevelopment are scarce and rarely scalable for clinical use. Direct recordings of cortical activity using routinely acquired electroencephalography (EEG) offer reliable measures of brain function. MethodsWe developed and validated a measure of functional brain age (FBA) using a residual neural network-based interpretation of the paediatric EEG. In this cross-sectional study, we included 1056 children with typical development ranging in age from 1 month to 18 years. We analyzed a 10 to 15 minute segment of 18-channel EEG recorded during light sleep (N1 and N2 states). FindingsThe FBA obtained from EEG had a weighted mean absolute error (wMAE) of 0.85 years (95%CI: 0.69-1.02; n = 1056). A two-channel version of the FBA had a wMAE of 1.51 years (95%CI: 1.30-1.73; n = 1056) and was validated on an independent set of EEG recordings (wMAE = 2.27 years, 95%CI: 1.90-2.65; n = 723). Group-level maturational delays were also detected in a small cohort of children with Trisomy 21 (Cohens d = 0.36, p = 0.028). InterpretationAn FBA, based on EEG, is an accurate, practical and scalable automated tool to track brain function maturation throughout childhood with accuracy comparable to widely used physical growth charts. FundingThis research was supported by the National Health and Medical Research Council, Australia, Helsinki University Diagnostic Center Research Funds, Finnish Academy, Finnish Paediatric Foundation, and Sigrid Juselius Foundation. RESEARCH IN CONTEXTO_ST_ABSEvidence before this studyC_ST_ABSTools for objectively tracking neurodevelopment in paediatric populations using direct measurement of the brain are rare. Prior to conducting this study, we explored multiple databases (Google Scholar, PubMed, Web of Science) with search strategies that combined one or more of the terms "paediatric brain development", "brain age", "age estimation", "MRI measurements", "EEG measurements", "machine learning", "artificial intelligence", "advanced ageing", "neurodevelopmental delays" and "growth charts" with no restrictions on language and dates. In screening over 500 publications, 7 studies evaluated brain age in children using MRI and only a single study investigated maturation in EEG activity across discrete age bins. Added value of this studyWe formulated a measure of functional brain age (FBA) using state-of-the-art machine learning (ML) algorithms trained on a large, unique database consisting of multichannel clinical EEG recorded from N1/N2 sleep (n = 1056 children; 1 month to 17 years), with typical neurodevelopment confirmed at a 4-year follow-up. The FBA showed a high correlation with age and detected group-level differences associated with conditions of neurodevelopmental delay. Implications of all the available evidenceAge is prominent within EEG recordings of N1/N2 sleep and is readily extracted using ML. Public release of the FBA estimator and the use of EEG, commonly delivered in outpatient settings, as the basis of age prediction enables clear translation of measures of brain age to the clinic. Future work on EEG datasets across various neurodevelopmental profiles will enhance generalisability and user confidence in the clinical application of brain age.