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bioRxiv · 10.1101/2023.07.04.547719

Design, Synthesis, and Biological Evaluation of Novel Mitochondria-targeting Exosomes

Yan, X.·Chen, X.·Shan, Z.·Bi, L.
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Abstract

Mitochondrial dysfunction is implicated in both brain tumors and neurodegenerative diseases, leading to various cellular abnormalities that can promote tumor growth and resistance to thera-pies, as well as impaired energy production and compromised neuronal function. Developing targeted therapies aimed at restoring mitochondrial function and improving overall cellular health could potentially be a promising approach to treating these conditions. Brain-derived exosomes (BR-EVs) have emerged as potential drug delivery vessels for neurological conditions. Herein, we report a new method for creating mitochondria-targeting exosomes and test its application in vitro and in vivo.

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Yan, X., Chen, X., Shan, Z., Bi, L.. 2023-07-04. Design, Synthesis, and Biological Evaluation of Novel Mitochondria-targeting Exosomes. https://doi.org/10.1101/2023.07.04.547719

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