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bioRxiv · 10.1101/2023.06.30.547194

In vivo magnetic recording of single-neuron action potentials

Abstract

Measuring fast neuronal signals is the domain of electrophysiology and magnetophysiology. While electrophysiology is easier to perform, magnetophysiology avoids tissue-based distortions and measures a signal with directional information. At the macroscale, magnetoencephalography (MEG) is established, and at the mesoscale, visually evoked magnetic fields have been reported. At the microscale however, while benefits of recording magnetic counterparts of electric spikes would be numerous, they are also highly challenging in vivo. Here, we combine magnetic and electric recordings of neuronal action potentials in anesthetized rats using miniaturized giant magneto-resistance (GMR) sensors. We reveal the magnetic signature of action potentials of well-isolated single units. The recorded magnetic signals showed a distinct waveform and considerable signal strength. This demonstration of in vivo magnetic action potentials opens a wide field of possibilities to profit from the combined power of magnetic and electric recordings and thus to significantly advance the understanding of neuronal circuits. Significance statementElectrophysiological tools allow the measurement of single-neuron action potentials with high temporal resolution. Magnetophysiological measurements would add valuable information, but are particularly hard to achieve for single neurons. Established technology for non-invasive magnetic brain signal measurements can currently not be used inside living tissue. Here, we demonstrate that miniaturized magnetic sensors based on giant magneto-resistance enable the measurement of the magnetic counterpart of single-neuron action potentials in vivo. This proof-of-principle shows a way towards integrating magnetic and electric recordings in future experiments and thus to profit from the complementary information measured by the two modalities.

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BibTeXRIS

Klein, F. J., Jendritza, P., Chopin, C., Parto-Dezfouli, M., Solignac, A., Fermon, C., Pannetier-Lecoeur, M., Fries, P.. 2023-07-02. In vivo magnetic recording of single-neuron action potentials. https://doi.org/10.1101/2023.06.30.547194

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