In-vivo whole-cortex estimation of excitation-inhibition ratio indexes cortical maturation and cognitive ability in youth

Zhang, S.; Larsen, B.; Sydnor, V. J.; Zeng, T.; An, L.; Yan, X.; Kong, R.; Kong, X.; Gur, R. C.; Gur, R. E.; Moore, T. M.; Wolf, D. H.; Holmes, A. J.; Xie, Y.; Zhou, J. H.; Fortier, M. V.; Tan, A. P.; Gluckman, P.; Chong, Y. S.; Meaney, M.; Deco, G.; Satterthwaite, T. D.; Yeo, B. T. T.

doi:10.1101/2023.06.22.546023

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bioRxiv · 10.1101/2023.06.22.546023

In-vivo whole-cortex estimation of excitation-inhibition ratio indexes cortical maturation and cognitive ability in youth

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Abstract

A balanced excitation-inhibition ratio (E/I ratio) is critical for healthy brain function. Normative development of cortex-wide E/I ratio remains unknown. Here we non-invasively estimate a putative marker of whole-cortex E/I ratio by fitting a large-scale biophysically-plausible circuit model to resting-state functional MRI (fMRI) data. We first confirm that our model generates realistic brain dynamics in the Human Connectome Project. Next, we show that the estimated E/I ratio marker is sensitive to the GABA-agonist benzodiazepine alprazolam during fMRI. Alprazolam-induced E/I changes are spatially consistent with positron emission tomography measurement of benzodiazepine receptor density. We then investigate the relationship between the E/I ratio marker and neurodevelopment. We find that the E/I ratio marker declines heterogeneously across the cerebral cortex during youth, with the greatest reduction occurring in sensorimotor systems relative to association systems. Importantly, among children with the same chronological age, a lower E/I ratio marker (especially in association cortex) is linked to better cognitive performance. This result is replicated across North American (8.2 to 23.0 years old) and Asian (7.2 to 7.9 years old) cohorts, suggesting that a more mature E/I ratio indexes improved cognition during normative development. Overall, our findings open the door to studying how disrupted E/I trajectories may lead to cognitive dysfunction in psychopathology that emerges during youth. SignificanceHealthy brain function requires a delicate balance of neural excitation (E) and inhibition (I). In animals, this balance - the E/I ratio - is known to decrease with the maturation of inhibitory circuitry during healthy development. However, in humans, the normative development of cortex-wide E/I ratio remains unclear. Here, we use a biophysical model and non-invasive brain scans to estimate a marker of E/I ratio. Spatial changes in our E/I ratio marker are consistent with a drug that decreases E/I ratio. We also find that our cortex-wide E/I ratio marker decreases during development. Furthermore, North American and Asian children with lower E/I ratio, especially in higher-order cortex, have better cognitive performance. Overall, E/I ratio is a potential index of healthy neurocognitive development.

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Zhang, S., Larsen, B., Sydnor, V. J., Zeng, T., An, L., Yan, X., Kong, R., Kong, X., Gur, R. C., Gur, R. E., Moore, T. M., Wolf, D. H., Holmes, A. J., Xie, Y., Zhou, J. H., Fortier, M. V., Tan, A. P., Gluckman, P., Chong, Y. S., Meaney, M., Deco, G., Satterthwaite, T. D., Yeo, B. T. T.. 2023-06-22. In-vivo whole-cortex estimation of excitation-inhibition ratio indexes cortical maturation and cognitive ability in youth. https://doi.org/10.1101/2023.06.22.546023

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