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bioRxiv · 10.1101/2023.05.23.541883

THE POSSIBILITY OF AN EXTENSION OF CATARACT TREATMENT BEYOND EYE SURGERY: A NOVEL NON-INVASIVE PHOTOBLEACHING OF THE HUMAN LENS BY LED

Smith, S. D.·Dhillon, B.
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Abstract

As discussed below cataract is the world-leading cause of blindness and impaired vision with only eye surgery as a treatment. There is major requirement for an alternative which this research has provided via Genetically Modified pigs with natural cataract making live animal experiments of LED photobleaching successful monitored by fluorescence spectra. The latter were shown by EBS as spectrally identical in pigs and humans. EBS developed a miniature fluorescence spectrometer via tunable interference filters with fluorescence excited by an LED. A second LED in the blue/violet region provided a 20mW treatment beam which was shown to reverse the fluorescence signal and dramatically improve the transmission of pigs eyes. These results led to permission for early Human Trials. The results were judged by independent optometrists by LOCS and fluorescence in pigs and in Human Trials by LOCS and Visual Acuity. Adequate positive results have led to full length Human Trials being conducted in four European countries. Prospects of worldwide application have been therefore indicated.

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Smith, S. D., Dhillon, B.. 2023-05-24. THE POSSIBILITY OF AN EXTENSION OF CATARACT TREATMENT BEYOND EYE SURGERY: A NOVEL NON-INVASIVE PHOTOBLEACHING OF THE HUMAN LENS BY LED. https://doi.org/10.1101/2023.05.23.541883

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