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bioRxiv · 10.1101/2023.05.18.541297

Neural representations of economic decision variables in human posterior parietal cortex

Abstract

Decision making has been intensively studied in the posterior parietal cortex in non-human primates on a single neuron level. In humans decision making has mainly been studied with psychophysical tools or with fMRI. Here, we investigated how single neurons from human posterior parietal cortex represent numeric values informing future decisions during a complex two-player game. The tetraplegic study participant was implanted with a Utah electrode array in the anterior intraparietal area (AIP). We played a simplified variant of Black Jack with the participant while neuronal data was recorded. During the game two players are presented with numbers which are added up. Each time a number is presented the player has to decide to proceed or to stop. Once the first player stops or the score reaches a limit the turn passes on to the second player who tries to beat the score of the first player. Whoever is closer to the limit (without overshooting) wins the game. We found that many AIP neurons selectively responded to the face value of the presented number. Other neurons tracked the cumulative score or were selectively active for the upcoming decision of the study participant. Interestingly, some cells also kept track of the opponents score. Our findings show that parietal regions engaged in hand action control also represent numbers and their complex transformations. This is also the first demonstration of complex economic decisions being possible to track in single neuron activity in human AIP. Our findings show how tight are the links between parietal neural circuits underlying hand control, numerical cognition and complex decision-making.

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BibTeXRIS

Klaes, C., Pilacinski, A., Kellis, S., Aflalo, T., Liu, C., Andersen, R.. 2023-05-18. Neural representations of economic decision variables in human posterior parietal cortex. https://doi.org/10.1101/2023.05.18.541297

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