Genome-wide coancestry reveals details of ancient and recent male-driven reticulation in baboons

Sorensen, E. F.; Harris, R. A.; Zhang, L.; Raveendran, M.; Kuderna, L. F. K.; Walker, J. A.; Storer, J. M.; Kuhlwilm, M.; Fontsere, C.; Seshadri, L.; Bergey, C. M.; Burrell, A. S.; Bergmann, J.; Phillips-Conroy, J. E.; Shiferaw, F.; Chiou, K. L.; Chuma, I. S.; Keyyu, J. D.; Fischer, J.; Gingras, M.-C.; Salvi, S.; Doddapaneni, H.; Schierup, M. H.; Batzer, M. A.; Jolly, C. J.; Knauf, S.; Zinner, D.; Farh, K. K.- H.; Marques-Bonet, T.; Munch, K.; Roos, C.; Rogers, J.

doi:10.1101/2023.05.02.539112

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bioRxiv · 10.1101/2023.05.02.539112

Genome-wide coancestry reveals details of ancient and recent male-driven reticulation in baboons

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Abstract

Baboons (genus Papio) are a morphologically and behaviorally diverse clade of catarrhine monkeys that have experienced hybridization between phenotypically and genetically distinct phylogenetic species. We used high coverage whole genome sequences from 225 wild baboons representing 19 geographic localities to investigate population genomics and inter-species gene flow. Our analyses provide an expanded picture of evolutionary reticulation among species and reveal novel patterns of population structure within and among species, including differential admixture among conspecific populations. We describe the first example of a baboon population with a genetic composition that is derived from three distinct lineages. The results reveal processes, both ancient and recent, that produced the observed mismatch between phylogenetic relationships based on matrilineal, patrilineal, and biparental inheritance. We also identified several candidate genes that may contribute to species-specific phenotypes. One-Sentence SummaryGenomic data for 225 baboons reveal novel sites of inter-species gene flow and local effects due to differences in admixture.

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Sorensen, E. F., Harris, R. A., Zhang, L., Raveendran, M., Kuderna, L. F. K., Walker, J. A., Storer, J. M., Kuhlwilm, M., Fontsere, C., Seshadri, L., Bergey, C. M., Burrell, A. S., Bergmann, J., Phillips-Conroy, J. E., Shiferaw, F., Chiou, K. L., Chuma, I. S., Keyyu, J. D., Fischer, J., Gingras, M.-C., Salvi, S., Doddapaneni, H., Schierup, M. H., Batzer, M. A., Jolly, C. J., Knauf, S., Zinner, D., Farh, K. K.- H., Marques-Bonet, T., Munch, K., Roos, C., Rogers, J.. 2023-05-02. Genome-wide coancestry reveals details of ancient and recent male-driven reticulation in baboons. https://doi.org/10.1101/2023.05.02.539112

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