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bioRxiv · 10.1101/2023.05.02.539011

Spatial transcriptomic analysis of adult hippocampal neurogenesis in the human brain

Simard, S.·Rahimian, R.·Davoli, M. A.·Theberge, S.·Matosin, N.·Turecki, G.·Nagy, C.·Mechawar, N.
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Abstract

Using spatial transcriptomics and FISH, we detected very few cells expressing neural stem cell- and proliferation-specific genes in the human dentate gyrus (DG) from childhood to middle age. However, we observed at all ages a significant number of DG cells expressing the immature neuronal marker DCX. Across ages, the majority of these cells displayed an inhibitory phenotype, while the remainder were non-committed or excitatory in nature.

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Simard, S., Rahimian, R., Davoli, M. A., Theberge, S., Matosin, N., Turecki, G., Nagy, C., Mechawar, N.. 2023-05-02. Spatial transcriptomic analysis of adult hippocampal neurogenesis in the human brain. https://doi.org/10.1101/2023.05.02.539011

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