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bioRxiv · 10.1101/2023.04.17.537130

Integrin beta4 promotes DNA damage drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/Rac1

Fang, H.·Ren, W.·Cui, Q.·Liang, H.·Yang, C.·Liu, W.·Wang, X.·Liu, X.·Shi, Y.·Feng, J.·Chen, C.
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Abstract

Anti-tumor drug resistance is a challenge for human triple-negative breast cancer treatment. Our previous work demonstrated that TNFAIP2 activates RAC1 to promote triple-negative breast cancer cell proliferation and migration. However, the mechanism by which TNFAIP2 activates RAC1 is unknown. In this study, we found that TNFAIP2 interacts with IQGAP1 and Integrin {beta}4. Integrin {beta}4 activates RAC1 through TNFAIP2 and IQGAP1 and confers DNA damage-related drug resistance in triple-negative breast cancer. These results indicate that the Integrin {beta}4/TNFAIP2/IQGAP1/RAC1 axis provides potential therapeutic targets to overcome DNA damage-related drug resistance in triple-negative breast cancer.

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Fang, H., Ren, W., Cui, Q., Liang, H., Yang, C., Liu, W., Wang, X., Liu, X., Shi, Y., Feng, J., Chen, C.. 2023-04-17. Integrin beta4 promotes DNA damage drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/Rac1. https://doi.org/10.1101/2023.04.17.537130

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