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bioRxiv · 10.1101/2023.03.31.535073

Induced neural phase precession through exogeneous electric fields

Abstract

The gradual shifting of preferred neural spiking relative to local field potentials (LFPs), known as phase precession, plays a prominent role in neural coding. Correlations between the phase precession and behavior have been observed throughout various brain regions. As such, phase precession is suggested to be a global neural mechanism that promotes local neuroplasticity. However, causal evidence and neuroplastic mechanisms of phase precession are lacking so far. Here we show a causal link between LFP dynamics and phase precession. In three experiments, we modulated LFPs in humans, a non-human primate, and computational models using alternating current stimulation. We show that continuous stimulation of motor cortex oscillations in humans lead to a gradual phase shift of maximal corticospinal excitability by [~]90{degrees}. Further, exogenous alternating current stimulation induced phase precession in a subset of entrained neurons ([~]30%) in the non-human primate. Multiscale modeling of realistic neural circuits suggests that alternating current stimulation-induced phase precession is driven by NMDA-mediated synaptic plasticity. Altogether, the three experiments provide mechanistic and causal evidence for phase precession as a global neocortical process. Alternating current-induced phase precession and consequently synaptic plasticity is crucial for the development of novel therapeutic neuromodulation methods.

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BibTeXRIS

Wischnewski, M., Tran, H., Zhao, Z., Shirinpour, S., Haigh, Z. J., Rotteveel, J., Alekseichuk, I., Zimmermann, J., Opitz, A.. 2023-04-02. Induced neural phase precession through exogeneous electric fields. https://doi.org/10.1101/2023.03.31.535073

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