Killing the enemy or making it your ally? The effects of thiostrepton on tumor associated macrophages

Pereira-Martins, D. A.; Hilberink, J.; Weinhauser, I.; Rego, E.; Huls, G.; Schuringa, J. J.

doi:10.1101/2023.03.23.533899

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bioRxiv · 10.1101/2023.03.23.533899

Killing the enemy or making it your ally? The effects of thiostrepton on tumor associated macrophages

Pereira-Martins, D. A.·Hilberink, J.·Weinhauser, I.·Rego, E.·Huls, G.·Schuringa, J. J.

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Abstract

Attempts to convert a tumor supportive M2-polarized macrophage microenvironment into a tumor suppressive M1-polarized one have recently received considerable attention. However, the specificity of novel compounds, their mode-of-action, and efficacy on presumed target cells in vivo needs to be interpreted with caution.

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Pereira-Martins, D. A., Hilberink, J., Weinhauser, I., Rego, E., Huls, G., Schuringa, J. J.. 2023-03-24. Killing the enemy or making it your ally? The effects of thiostrepton on tumor associated macrophages. https://doi.org/10.1101/2023.03.23.533899

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